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Numerous studies indicate that polyphenols including hydroxycinnamic acids (caffeic acid and curcumin), flavanols (quercetin, catechin, and epigallocatechin gallate), flavanones (hesperetin), isoflavones (genistein), anthocyanidins (cyanidin and procyanidin), and stilbenes (resveratrol), mainly in fresh fruit and vegetables, perform their anticarcinogenic mechanism through the upregulation of tumor suppressors and autophagy by modulating some metabolic signaling pathways, thus reducing the risk of HCC [48,49]

More substantial changes in skin firmness and resilience, which involve actual collagen remodeling, typically take eight to twelve weeks to become visible

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